Famous American singer Carly Simon revealed that the first symptoms of Parkinson’s disease were confused with arthritis. The artist, best known for "You're So Vain," said in a written statement that she thought her walking difficulty after knee and hip replacement surgeries was part of the lengthy recovery process.
Simon said, "I had arthritis in both knees and one hip; I had all three joints replaced. I thought my walking difficulty was part of the long recovery process. However, when I experienced periods when I couldn't walk without help, my family and I realized there was more to it. An extensive evaluation at Mayo Clinic led to a Parkinson's diagnosis."
According to the Centers for Disease Control and Prevention (CDC), arthritis, which affects about 60 million adults in the U.S., is far more common than Parkinson's. The number of Parkinson's patients is around 1.1 million, with about 90,000 new diagnoses each year.
Similar symptoms make diagnosis difficult
Dr. Guy Schwartz, a neurologist at Stony Brook Medicine in New York, said the two conditions can show similar symptoms, especially in the early stages. Schwartz noted, "Parkinson's can sometimes be mistaken for arthritis, and arthritis for Parkinson's. The most common complaint is difficulty walking—a kind of obstacle or limitation."
Experts list the main symptoms that the two diseases can share as follows:
- Joint or limb stiffness
- Walking disorder or gait change
- Reduced range of motion
- Difficulty initiating movement and slowness
- Balance problems and feeling of unsteadiness
- Pain and soreness
- Fatigue
- Difficulty performing daily tasks
Dr. Schwartz also pointed out that both conditions can coexist in the same person, especially with advanced age: "Examination findings can be confusing, particularly in patients with pronounced arthritis."
Signs specific to Parkinson's
The Parkinson's Foundation highlights the following symptoms that tend to appear only in Parkinson's:
- Resting tremor, typically starting on one side
- Small handwriting (micrographia)
- Reduced arm swing while walking
- Softening of the voice or lower vocal pitch
- Decreased facial expression, mask-like face
- Slowness of movement (bradykinesia)
- Loss of smell
- REM sleep behavior disorder (acting out dreams)
- Constipation that can start before movement symptoms
Schwartz stresses that tremor does not always occur: "Roughly a third of Parkinson's patients have no tremor. That's when diagnosis becomes even more challenging. In Parkinson's, clumsiness stems from slowness and rigidity, whereas in arthritis it is more of a mechanical restriction."
How does the diagnosis process work?
Since both diseases rely heavily on symptoms and physical examination, differential diagnosis can be difficult. According to the National Institute of Neurological Disorders and Stroke, the following factors are evaluated in diagnosis: detailed medical history; neurological examination that detects symptoms such as tremor, slow movement, and balance problems; physical examination measuring movement and reflexes; response to Parkinson's medications; and tests to rule out other conditions.
Neurologist Schwartz noted that new diagnostic tools such as specialized imaging and skin biopsies are developing, but there is still no single blood test that gives a result: "Very few things in medicine are 100 percent. Sometimes seeing the patient over time provides the best way; the disease reveals itself and diagnosis becomes easier. Misdiagnoses are not unusual."
Schwartz recommended that anyone experiencing walking difficulty or stiffness that cannot be fully explained by arthritis and becomes persistent should consult a healthcare provider, and undergo neurological evaluation if necessary.